Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model

Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model

Cross-relaxation imaging (CRI) is a quantitative magnetic resonance technique that measures the kinetic parameters of magnetization transfer between protons bound to water and protons bound to macromolecules. In this study, in vivo, four-parameter CRI of normal rat brains (N=5) at 3.0 T was first di...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2011-02, Vol.54 (3), p.2052-2065
Hauptverfasser: Underhill, Hunter R., Rostomily, Robert C., Mikheev, Andrei M., Yuan, Chun, Yarnykh, Vasily L.
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Animals
Axons - physiology
Bound pool fraction
Brain - anatomy & histology
Brain - pathology
Brain cancer
Brain Neoplasms - pathology
Cell Count
Cell Line, Tumor
Cross-relaxation imaging
Fractions
Glioma
Glioma - pathology
Histology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Magnetization transfer ratio
Male
Models, Statistical
Myelin
Myelin Sheath - pathology
Nerve Fibers, Myelinated - metabolism
Nerve Fibers, Myelinated - pathology
Quantitative magnetization transfer
Rat brain
Rats
Rats, Inbred WF
Rats, Wistar
Reproducibility of Results
Studies
Tissue Fixation
Tumors
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Zusammenfassung:Cross-relaxation imaging (CRI) is a quantitative magnetic resonance technique that measures the kinetic parameters of magnetization transfer between protons bound to water and protons bound to macromolecules. In this study, in vivo, four-parameter CRI of normal rat brains (N=5) at 3.0 T was first directly compared to histology. The bound pool fraction, f, was strongly associated with myelin density (Pearson's r=0.99, p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.10.065