A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN

Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-09, Vol.46 (36), p.6747-6749
Hauptverfasser:	Garber, Kathleen C A, Wangkanont, Kittikhun, Carlson, Erin E, Kiessling, Laura L
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - metabolism HIV Infections - transmission Humans Lectins, C-Type - antagonists & inhibitors Lectins, C-Type - metabolism Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - metabolism Shikimic Acid - chemistry Small Molecule Libraries - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c0cc00830c