Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

OBJECTIVE: To test if knowledge of type 2 diabetes genetic variants improves disease prediction. RESEARCH DESIGN AND METHODS: We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regress...

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Veröffentlicht in:Diabetes care 2011-01, Vol.34 (1), p.121-125
Hauptverfasser: de Miguel-Yanes, Jose M, Shrader, Peter, Pencina, Michael J, Fox, Caroline S, Manning, Alisa K, Grant, Richard W, Dupuis, Josèe, Florez, Jose C, D'Agostino, Ralph B. Sr, Cupples, L. Adrienne, Meigs, James B
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Sprache:eng
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Zusammenfassung:OBJECTIVE: To test if knowledge of type 2 diabetes genetic variants improves disease prediction. RESEARCH DESIGN AND METHODS: We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (
ISSN:0149-5992
1935-5548
DOI:10.2337/dc10-1265