Differential Impact of Adherence to Pegylated Interferon and Ribavirin in the Treatment of Genotype 1 High Viral Titer Chronic Hepatitis C

Differential Impact of Adherence to Pegylated Interferon and Ribavirin in the Treatment of Genotype 1 High Viral Titer Chronic Hepatitis C

To clarify the impact of adherence, we treated 122 genotype 1 high viral titer chronic hepatitis C patients with pegylated interferon (peg-IFN) and ribavirin for 48 weeks at nine referral hospitals, and evaluated the prognostic factors with a focus on the adherence to the treatment. This study inclu...

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Veröffentlicht in:Hepatitis Research and Treatment 2010-01, Vol.2010 (2010), p.114-119
Hauptverfasser: Shiraishi, Koichi, Nagata, Naruhiko, Hirose, Shunji, Kojima, Sei-ichiro, Kagawa, Tatehiro, Numata, Makoto, Watanabe, Norihito, Shiozawa, Hirokazu, Nishizaki, Yasuhiro, Motegi, Shigeyuki, Takashimizu, Shinji, Kamochi, Jun-ichiro, Wasada, Mitsuru, Ohno, Takashi, Tei, Yoshihiro, Nakano, Atsushi, Yamada, Takuji, Atsukawa, Kazuhiro, Watanabe, Tetsu, Mine, Tetsuya
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Sprache:eng
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Clinical Study
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Zusammenfassung:To clarify the impact of adherence, we treated 122 genotype 1 high viral titer chronic hepatitis C patients with pegylated interferon (peg-IFN) and ribavirin for 48 weeks at nine referral hospitals, and evaluated the prognostic factors with a focus on the adherence to the treatment. This study included 68 (55.7%) treatment-naïve patients and 54 (44.3%) patients who did not respond to the previous treatment. Multivariate analysis revealed adherence to peg-IFN and ribavirin as the only significant predictor. Sustained virological response (SVR) rate was 72.2%, 19.0%, and 27.3% in patients given ≥80%, 60%–80%, and
ISSN:2090-1364
2090-1372
DOI:10.1155/2010/702748