The ABC of clinical and experimental adjuvants—A brief overview

Abstract Adjuvants are compounds that can increase and/or modulate the intrinsic immunogenicity of an antigen and elicit strong and long lasting immune responses. During the last 80 years many adjuvants have been used in experimental settings, but due to various shortcomings of most of them only alu...

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Veröffentlicht in:	Immunology letters 2010-01, Vol.128 (1), p.29-35
Hauptverfasser:	Brunner, Richard, Jensen-Jarolim, Erika, Pali-Schöll, Isabella
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Allergy and Immunology Aluminum Aluminum Compounds - immunology Aluminum Compounds - therapeutic use Animals Bacterial Toxins - immunology Cholera toxin B Flagellin Flagellin - immunology Freund's Adjuvant - immunology Freund’s adjuvant Humans Immune response Lipid A - analogs & derivatives Lipid A - immunology MF59 Monophosphoryl lipid A Nanoparticles Poly-lactid-co-glycolid acid Polysorbates Squalene - immunology Vaccines Virosomes Virosomes - immunology
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Zusammenfassung:	Abstract Adjuvants are compounds that can increase and/or modulate the intrinsic immunogenicity of an antigen and elicit strong and long lasting immune responses. During the last 80 years many adjuvants have been used in experimental settings, but due to various shortcomings of most of them only aluminum compounds made it into regular clinical usage. However, during the last years promising candidates have arisen that may finally adjunct or displace aluminum substances as main adjuvant. This review summarizes information on adjuvants currently used in clinical as well as in experimental settings.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2009.10.005