Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection

We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly higher than those in patients without pneumonia. This tendency was also present for IL-6, IL...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 2011-01, Vol.30 (1), p.117-120
Hauptverfasser:	Takano, T, Tajiri, H, Kashiwagi, Y, Kimura, S, Kawashima, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Biological and medical sciences Biomedical and Life Sciences Biomedicine Brief Report Chemokines Child Child, Preschool Convulsions & seizures Cytokines Cytokines - blood Delirium Epidemics Female Human viral diseases Humans Hypoxia Illnesses Infections Infectious diseases Influenza A Virus, H1N1 Subtype - immunology Influenza, Human - complications Influenza, Human - immunology Internal Medicine Laboratories Male Medical Microbiology Medical sciences Pandemics Pediatrics Pneumonia Pneumonia - immunology Pneumonia - pathology Respiratory failure Swine flu Ventilators Viral diseases Viral diseases of the respiratory system and ent viral diseases
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Zusammenfassung:	We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly higher than those in patients without pneumonia. This tendency was also present for IL-6, IL-8, IL-10, IL-13, and MCP-1 in patients with pneumonia. Among patients with pneumonia, the levels of MCP-1 were significantly higher in the group of patients with pneumonia with severe respiratory failure than patients with mild pneumonia.
ISSN:	0934-9723 1435-4373
DOI:	10.1007/s10096-010-1041-9