The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population

The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients. Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients...

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Veröffentlicht in:	Molecular vision 2010-10, Vol.16, p.2146-2152
Hauptverfasser:	Khan, Muhammad Imran, Micheal, Shazia, Akhtar, Farah, Ahmed, Waqar, Ijaz, Bushra, Ahmed, Asifa, Qamar, Raheel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Chromosome Segregation - genetics Exfoliation Syndrome - complications Exfoliation Syndrome - enzymology Exfoliation Syndrome - genetics Female Genetic Association Studies Genetic Predisposition to Disease Glaucoma - complications Glaucoma - enzymology Glaucoma - genetics Glutathione Transferase - genetics Humans Male Pakistan Polymerase Chain Reaction Polymorphism, Single Nucleotide - genetics Sex Characteristics
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Zusammenfassung:	The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients. Multiplex polymerase chain reaction was used to study the GSTT1 and GSTM1 polymorphisms in 165 PEXG patients and 162 unaffected controls. In the current study we describe a significant gender-specific association of GSTT1 and GSTM1 null genotypes with PEXG. The three null genotype combinations (i.e., T1M0, T0M1, and T0M0) were found at significantly higher frequencies in the PEXG patients as compared to the controls (χ(2)=21.82, p
ISSN:	1090-0535 1090-0535