Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the r...

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Veröffentlicht in:Tetrahedron letters 2009-12, Vol.50 (50), p.7028-7031
Hauptverfasser: Alapafuja, Shakiru O., Nikas, Spyros P., Shukla, Vidyanand G., Papanastasiou, Ioannis, Makriyannis, Alexandros
Format: Artikel
Sprache:eng
Schlagworte:
Microwave
Sodium sulfonates
Sulfonyl chlorides
Sulfonyl fluorides
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Zusammenfassung:We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.09.167