Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2003-01, Vol.299 (5604), p.247-251
Hauptverfasser: Abtahian, Farhad, Guerriero, Anastasia, Sebzda, Eric, Lu, Min-Min, Zhou, Rong, Mocsai, Attila, Myers, Erin E., Huang, Bin, Jackson, David G., Ferrari, Victor A., Tybulewicz, Victor, Lowell, Clifford A., Lepore, John J., Koretzky, Gary A., Kahn, Mark L.
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Sprache:eng
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Zusammenfassung:Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76-deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1079477