Modular Peptide Growth Factors for Substrate-Mediated Stem Cell Differentiation

The sequence specificity of the binding of a modular peptide growth factor (eBGa3) that contains a BMP2‐derived sequence and a mineral‐binding sequence inspired by osteocalcin to calcium ions of hydroxyapatite (HA) may be attributed in part to evolution of an α‐helical structure in the presence of H...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-01, Vol.48 (34), p.6266-6269
Hauptverfasser:	Lee, Jae Sam, Lee, Jae Sung, Wagoner-Johnson, Amy, Murphy, William L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence biomineralization Bone Morphogenetic Protein 2 - chemistry Cell Differentiation Cells, Cultured Durapatite - chemistry Humans hydroxyapatite Intercellular Signaling Peptides and Proteins - chemistry Intercellular Signaling Peptides and Proteins - pharmacology Molecular Sequence Data osteocalcin Osteocalcin - metabolism osteogenesis Peptides - chemistry Peptides - pharmacology protein modifications Stem Cells - cytology Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The sequence specificity of the binding of a modular peptide growth factor (eBGa3) that contains a BMP2‐derived sequence and a mineral‐binding sequence inspired by osteocalcin to calcium ions of hydroxyapatite (HA) may be attributed in part to evolution of an α‐helical structure in the presence of HA, which allows for registration of γ‐carboxylated glutamic acid residues in the peptide (cyan) with calcium atoms (orange) in the HA crystal lattice.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200901618