Unaltered Negative Selection and Regulatory T cell Development of Self-reactive thymocytes in TCR transgenic Fyn-deficient Mice

The tyrosine kinase Fyn has been implicated as playing an important role in the generation of both stimulatory and inhibitory signaling events induced by TCR engagement. To assess the role of Fyn for antigen-driven negative selection and regulatory T cell (Treg) development, which are both dependent...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of immunology 2010-02, Vol.40 (2), p.539-547
Hauptverfasser:	Mamchak, Alusha A., Thien, Christine B.F., Dagger, Samantha A., Lyandres, Julia, Jiang, Shuwei, Langdon, Wallace Y., DeFranco, Anthony L.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!