Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2009-08, Vol.74 (16), p.6169-6180
Hauptverfasser:	Goodell, John R, McMullen, Jonathan P, Zaborenko, Nikolay, Maloney, Jason R, Ho, Chuan-Xing, Jensen, Klavs F, Porco, John A, Beeler, Aaron B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Applied sciences Automation Bridged Bicyclo Compounds - chemistry Chemical engineering Chemistry Equipment Design Exact sciences and technology Indicators and Reagents - chemistry Kinetics Microfluidic Analytical Techniques - instrumentation Organic chemistry Preparations and properties Reactors Solvents - chemistry Temperature
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Beschreibung
Zusammenfassung:	An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo901073v