Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography

We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the R...

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Veröffentlicht in:Optics express 2008-10, Vol.16 (21), p.16410-16422
Hauptverfasser: Götzinger, Erich, Pircher, Michael, Geitzenauer, Wolfgang, Ahlers, Christian, Baumann, Bernhard, Michels, Stephan, Schmidt-Erfurth, Ursula, Hitzenberger, Christoph K
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Sprache:eng
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Zusammenfassung:We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.
ISSN:1094-4087
1094-4087
DOI:10.1364/oe.16.016410