BNP controls early load-dependent regulation of SERCA through calcineurin

Heart failure is characterised by reduced expression of sarcoplasmic reticulum calcium-ATPase (SERCA) and increased expression of B-type natriuretic peptide (BNP). The present study was performed to investigate causality of this inverse relationship under in vivo conditions in the transversal aortic...

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Veröffentlicht in:	Basic research in cardiology 2010-11, Vol.105 (6), p.795-804
Hauptverfasser:	Toischer, Karl, Teucher, Nils, Unsöld, Bernhard, Kuhn, Michaela, Kögler, Harald, Hasenfuss, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Natriuretic Factor - metabolism Calcineurin - metabolism Cardiology Cyclic GMP - metabolism Disease Models, Animal Female Guanylate Cyclase - metabolism Heart Failure - enzymology Heart Failure - physiopathology LIM Domain Proteins Medicine Medicine & Public Health Mice Mice, Knockout Mice, Transgenic Muscle Proteins - deficiency Muscle Proteins - genetics Myocardial Contraction Natriuretic Peptide, Brain - metabolism NFATC Transcription Factors - genetics Original Contribution Receptors, Atrial Natriuretic Factor - deficiency Receptors, Atrial Natriuretic Factor - genetics RNA, Messenger - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Time Factors Up-Regulation
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Zusammenfassung:	Heart failure is characterised by reduced expression of sarcoplasmic reticulum calcium-ATPase (SERCA) and increased expression of B-type natriuretic peptide (BNP). The present study was performed to investigate causality of this inverse relationship under in vivo conditions in the transversal aortic constriction mouse model (TAC). Left ventricular SERCA-mRNA expression was significantly upregulated in TAC by 32% after 6 h, but not different from sham after 24 h. Serum proANP and BNP levels were increased in TAC after 24 h (BNP +274%, p
ISSN:	0300-8428 1435-1803
DOI:	10.1007/s00395-010-0115-2