Reversing the Effects of Fragile X Syndrome

A research on how synaptic plasticity is abnormally regulated in fragile X syndrome and how this abnormality can be reversed by therapeutic interventions is presented. Fragile X syndrome is a disorder of synaptic plasticity that contributes to abnormal development and interferes with normal learning...

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Veröffentlicht in:	Journal of the American Academy of Child and Adolescent Psychiatry 2008-08, Vol.47 (8), p.863-867
Hauptverfasser:	Ogren, Marilee P, Lombroso, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Child clinical studies Dendrites - metabolism Fragile X Mental Retardation Protein - genetics Fragile X Syndrome - genetics Fragile X Syndrome - pathology Fragile X Syndrome - therapy Genetics Humans Intervention Learning Problems Medical sciences Memory Mental disorders Mental Retardation Mice Plastics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotherapy Receptor, Metabotropic Glutamate 5 Receptors, Glutamate - genetics Receptors, Glutamate - metabolism Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - genetics RNA, Messenger - genetics Spinal Cord - pathology
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Beschreibung
Zusammenfassung:	A research on how synaptic plasticity is abnormally regulated in fragile X syndrome and how this abnormality can be reversed by therapeutic interventions is presented. Fragile X syndrome is a disorder of synaptic plasticity that contributes to abnormal development and interferes with normal learning and memory.
ISSN:	0890-8567 1527-5418
DOI:	10.1097/CHI.0b0