Dengue hemorrhagic fever is associated with polymorphisms in JAK1

To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN)...

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Veröffentlicht in:	European journal of human genetics : EJHG 2010-11, Vol.18 (11), p.1221-1227
Hauptverfasser:	Silva, Luciano K, Blanton, Ronald E, Parrado, Antonio R, Melo, Paulo S, Morato, Vanessa G, Reis, Eliana AG, Dias, Juarez P, Castro, Jesuina M, Vasconcelos, Pedro FC, Goddard, Katrina AB, Barreto, Maurício L, Reis, Mitermayer G, Teixeira, M Glória
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144 631/208/457/649 631/326/596/1413 692/699/255/2514 Adolescent Adult Arboviroses Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedicine Black People - genetics Brazil - epidemiology Child Cytogenetics DC-SIGN protein Dengue fever Dengue fevers Dengue hemorrhagic fever Disease Epidemiology Ethnic groups Ethnicity Female Fever Fundamental and applied biological sciences. Psychology Gene Expression Gene Frequency General aspects. Genetic counseling Genetic Predisposition to Disease - genetics Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype Haplotypes Hospitalization Human Genetics Human viral diseases Humans Indians, South American - genetics Infections Infectious diseases Interferon JAK1 gene Janus kinase Janus Kinase 1 - genetics Male Medical genetics Medical sciences Molecular and cellular biology Polymorphism, Single Nucleotide Severe Dengue - ethnology Severe Dengue - genetics Single-nucleotide polymorphism Tropical viral diseases Viral diseases White People - genetics Young Adult
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Beschreibung
Zusammenfassung:	To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN) response pathway as well as other important candidate genes. By single locus analysis comparing DHF with DF, 11 of the 51 markers with P
ISSN:	1018-4813 1476-5438
DOI:	10.1038/ejhg.2010.98