Structural Determinants of Cadherin-23 Function in Hearing and Deafness

The hair-cell tip link, a fine filament directly conveying force to mechanosensitive transduction channels, is composed of two proteins, protocadherin-15 and cadherin-23, whose mutation causes deafness. However, their molecular structure, elasticity, and deafness-related structural defects are unkno...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2010-04, Vol.66 (1), p.85-100
Hauptverfasser:	Sotomayor, Marcos, Weihofen, Wilhelm A., Gaudet, Rachelle, Corey, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	AFFINITY Animals Binding Sites Cadherin Related Proteins Cadherins - chemistry Cadherins - metabolism CRYSTAL STRUCTURE Deafness - metabolism Deafness - physiopathology DEFECTS ELASTICITY Hair Hair Cells, Auditory - metabolism Hearing - physiology MATERIALS SCIENCE Mechanotransduction, Cellular - physiology Mice Models, Molecular MOLECULAR STRUCTURE MOLNEURO Mutation MUTATIONS Protein Conformation Protein Precursors - chemistry Protein Precursors - metabolism PROTEINS RESIDUES Simulation Structure-Activity Relationship
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