Mutated genes, pathways and processes in tumours
Integration of the many available sources of cancer gene information—such as large‐scale tumour‐resequencing studies— identifies the ‘usual suspect’ genes, mutated in many tumour types, as well as different sets of mutated genes according to the specific tumour type. Scaling‐up the analysis reveals...
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| Veröffentlicht in: | EMBO reports 2010-10, Vol.11 (10), p.805-810 |
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| creator | Baudot, Anaïs de la Torre, Victor Valencia, Alfonso |
| description | Integration of the many available sources of cancer gene information—such as large‐scale tumour‐resequencing studies— identifies the ‘usual suspect’ genes, mutated in many tumour types, as well as different sets of mutated genes according to the specific tumour type. Scaling‐up the analysis reveals that this large collection of mutated genes cluster into a smaller number of signalling pathways and processes. From this, we draw a map of the altered processes, and their combinations, in more than 10 tumours types. Literature searches identify pathways and processes that are covered sparsely in the literature, and invite the proposal of new hypotheses to investigate cancer initiation and progression.
This analysis of genes mutated in cancers, drawn from small and large‐scale genome studies, allows the authors to draw a map of pathways and processes altered by cancers, revealing both common and specific changes. |
| doi_str_mv | 10.1038/embor.2010.133 |
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This analysis of genes mutated in cancers, drawn from small and large‐scale genome studies, allows the authors to draw a map of pathways and processes altered by cancers, revealing both common and specific changes.</description><identifier>ISSN: 1469-221X</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.1038/embor.2010.133</identifier><identifier>PMID: 20847737</identifier><identifier>CODEN: ERMEAX</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>cancer-mutated genes ; Cluster Analysis ; Databases, Genetic ; EMBO24 ; EMBO37 ; EMBO43 ; Gene Expression Regulation, Neoplastic ; Genes ; Genes, Neoplasm ; Genetic Predisposition to Disease - genetics ; large-scale resequencing ; Multigene Family ; Mutation ; Neoplasms - genetics ; oncogenomics ; pathways ; Scientific Report ; Scientific Reports ; Signal Transduction ; systems biology ; Tumors</subject><ispartof>EMBO reports, 2010-10, Vol.11 (10), p.805-810</ispartof><rights>European Molecular Biology Organization 2010</rights><rights>Copyright © 2010 European Molecular Biology Organization</rights><rights>Copyright Nature Publishing Group Oct 2010</rights><rights>Copyright © 2010, European Molecular Biology Organization 2010 European Molecular Biology Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5423-8b517dee5078437a825536812467c409e57a8222cb766697e5786088d5f16e8e3</citedby><cites>FETCH-LOGICAL-c5423-8b517dee5078437a825536812467c409e57a8222cb766697e5786088d5f16e8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948187/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948187/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20847737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baudot, Anaïs</creatorcontrib><creatorcontrib>de la Torre, Victor</creatorcontrib><creatorcontrib>Valencia, Alfonso</creatorcontrib><title>Mutated genes, pathways and processes in tumours</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>Integration of the many available sources of cancer gene information—such as large‐scale tumour‐resequencing studies— identifies the ‘usual suspect’ genes, mutated in many tumour types, as well as different sets of mutated genes according to the specific tumour type. Scaling‐up the analysis reveals that this large collection of mutated genes cluster into a smaller number of signalling pathways and processes. From this, we draw a map of the altered processes, and their combinations, in more than 10 tumours types. Literature searches identify pathways and processes that are covered sparsely in the literature, and invite the proposal of new hypotheses to investigate cancer initiation and progression.
This analysis of genes mutated in cancers, drawn from small and large‐scale genome studies, allows the authors to draw a map of pathways and processes altered by cancers, revealing both common and specific changes.</description><subject>cancer-mutated genes</subject><subject>Cluster Analysis</subject><subject>Databases, Genetic</subject><subject>EMBO24</subject><subject>EMBO37</subject><subject>EMBO43</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genes, Neoplasm</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>large-scale resequencing</subject><subject>Multigene Family</subject><subject>Mutation</subject><subject>Neoplasms - genetics</subject><subject>oncogenomics</subject><subject>pathways</subject><subject>Scientific Report</subject><subject>Scientific Reports</subject><subject>Signal Transduction</subject><subject>systems biology</subject><subject>Tumors</subject><issn>1469-221X</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUlP6zAUhS30EPOW5VP0NmxI8RAP2SBBxQxFQiDYWW5yWwIZip0A_fc4pBR4EmJlX_u7x-f6ILRJcI9gpnagGFa2R3FbM7aAVkgk4pARqf7M9pSSu2W06twDxpjHUi2hZYpVJCWTKwhfNLWpIQ3GUILbDiamvn8xUxeYMg0mtkrAOXBBVgZ1U1SNdetocWRyBxuzdQ3dHB5c94_D88ujk_7eeZjwiLJQDTmRKQDHUkVMGkU5Z0IRGgmZRDgG3p5RmgylECKWvlYCK5XyERGggK2h3U530gwLSBMoa2tyPbFZYexUVybT32_K7F6Pq2dN40gRJb3A1kzAVk8NuFoXmUsgz00JVeO05DwWMYtb8t9_5IOftPTTtRAnTEXcQ70OSmzlnIXR3ArBuo1Cv0eh2yi0j8I3_P06wBz_-HsPyA54yXKY_iKnDy72r9qik97pOp1vKsdgPw3_aCbsOjJXw-v8LWMftfBeuL4dHOnTwfHg9kzcacreAPfos5s</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Baudot, Anaïs</creator><creator>de la Torre, Victor</creator><creator>Valencia, Alfonso</creator><general>John Wiley & Sons, Ltd</general><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201010</creationdate><title>Mutated genes, pathways and processes in tumours</title><author>Baudot, Anaïs ; de la Torre, Victor ; Valencia, Alfonso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5423-8b517dee5078437a825536812467c409e57a8222cb766697e5786088d5f16e8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>cancer-mutated genes</topic><topic>Cluster Analysis</topic><topic>Databases, Genetic</topic><topic>EMBO24</topic><topic>EMBO37</topic><topic>EMBO43</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes</topic><topic>Genes, Neoplasm</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>large-scale resequencing</topic><topic>Multigene Family</topic><topic>Mutation</topic><topic>Neoplasms - genetics</topic><topic>oncogenomics</topic><topic>pathways</topic><topic>Scientific Report</topic><topic>Scientific Reports</topic><topic>Signal Transduction</topic><topic>systems biology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baudot, Anaïs</creatorcontrib><creatorcontrib>de la Torre, Victor</creatorcontrib><creatorcontrib>Valencia, Alfonso</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Scaling‐up the analysis reveals that this large collection of mutated genes cluster into a smaller number of signalling pathways and processes. From this, we draw a map of the altered processes, and their combinations, in more than 10 tumours types. Literature searches identify pathways and processes that are covered sparsely in the literature, and invite the proposal of new hypotheses to investigate cancer initiation and progression.
This analysis of genes mutated in cancers, drawn from small and large‐scale genome studies, allows the authors to draw a map of pathways and processes altered by cancers, revealing both common and specific changes.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20847737</pmid><doi>10.1038/embor.2010.133</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | cancer-mutated genes Cluster Analysis Databases, Genetic EMBO24 EMBO37 EMBO43 Gene Expression Regulation, Neoplastic Genes Genes, Neoplasm Genetic Predisposition to Disease - genetics large-scale resequencing Multigene Family Mutation Neoplasms - genetics oncogenomics pathways Scientific Report Scientific Reports Signal Transduction systems biology Tumors |
| title | Mutated genes, pathways and processes in tumours |
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