Resolving the Relationship between Apolipoprotein E and Depression

Resolving the Relationship between Apolipoprotein E and Depression

Several studies have reported an association between the ApolipoproteinE-ε4 (APOE4) allele and depression among elders. However others have failed to find an association. Since APOE4 is a well recognized risk factor for Alzheimer dementia, cognitive status may represent an important confounder betwe...

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Veröffentlicht in:Neuroscience letters 2009-03, Vol.455 (2), p.116-119
Hauptverfasser: Slifer, Michael A., Martin, Eden R., Gilbert, John R., Haines, Jonathan L., Pericak-Vance, Margaret A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Several studies have reported an association between the ApolipoproteinE-ε4 (APOE4) allele and depression among elders. However others have failed to find an association. Since APOE4 is a well recognized risk factor for Alzheimer dementia, cognitive status may represent an important confounder between APOE4 and depression. In this investigation, we examined the relationship between the ApolipoproteinE-ε4 allele and depression among elders accounting for cognitive status.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2009.03.007