A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD

A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD

AKAP79/150 is a protein scaffold thought to position specific kinases (PKA, PKC) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we fou...

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Veröffentlicht in:Nature neuroscience 2010-08, Vol.13 (9), p.1053-1055
Hauptverfasser: Jurado, Sandra, Biou, Virginie, Malenka, Robert C.
Format: Artikel
Sprache:eng
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Zusammenfassung:AKAP79/150 is a protein scaffold thought to position specific kinases (PKA, PKC) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent LTD solely due to its interaction with calcineurin.
ISSN:1097-6256
1546-1726
DOI:10.1038/nn.2613