Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons

To determine factors associated with baseline neurocognitive performance in HIV-infected participants enrolled in the Strategies for Management of Antiretroviral Therapy (SMART) neurology substudy. Participants from Australia, North America, Brazil, and Thailand were administered a 5-test neurocogni...

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Veröffentlicht in:	Neurology 2010-09, Vol.75 (10), p.864-873
Hauptverfasser:	WRIGHT, E. J, GRUND, B, PENALVA DE OLIVEIRA, A. C, PUMPRADIT, W, SHLAY, J. C, EL-SADR, W, PRICE, R. W, ROBERTSON, K, BREW, B. J, ROEDIGER, M, BAIN, M. P, DRUMMOND, F, VJECHA, M. J, HOY, J, MILLER, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age antiretroviral therapy Antiviral agents Australia Batteries Biological and medical sciences Brazil Cardiovascular diseases Cardiovascular Diseases - complications Cardiovascular Diseases - psychology Cardiovascular Diseases - virology CD4 antigen Central nervous system Cognition Cognition - physiology Cognitive ability Dementia disorders Demography Female HIV Infections - complications HIV Infections - psychology HIV Infections - virology HIV Seropositivity - complications HIV Seropositivity - psychology HIV Seropositivity - virology Human immunodeficiency virus Human viral diseases Humans Hypercholesterolemia Hypercholesterolemia - complications Hypercholesterolemia - psychology Hypercholesterolemia - virology Hypertension Infectious diseases Male Medical sciences Middle Aged Neurology Neuropsychological Tests North America Races Regression Analysis Risk Factors Sex Thailand Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	To determine factors associated with baseline neurocognitive performance in HIV-infected participants enrolled in the Strategies for Management of Antiretroviral Therapy (SMART) neurology substudy. Participants from Australia, North America, Brazil, and Thailand were administered a 5-test neurocognitive battery. Z scores and the neurocognitive performance outcome measure, the quantitative neurocognitive performance z score (QNPZ-5), were calculated using US norms. Neurocognitive impairment was defined as z scores
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.0b013e3181f11bd8