The PI‐PLC inhibitor U‐73122 is a potent inhibitor of the SERCA pump in smooth muscle

In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U‐73122 can potently inhibit Ca2+ release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the sarcoplasmic/endoplasmic reticulum...

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Veröffentlicht in:	British journal of pharmacology 2010-07, Vol.160 (6), p.1293-1294
Hauptverfasser:	Hollywood, MA, Sergeant, GP, Thornbury, KD, McHale, NG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ca super(2+)-transporting ATPase Calcium Calcium - metabolism Data processing Endoplasmic reticulum Estrenes - pharmacology Humans Muscular system Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Phosphoinositide Phospholipase C - antagonists & inhibitors Phospholipase C PLC inhibition Pyrrolidinones - pharmacology Research Papers with Commentaries Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism SERCA pump inhibition Signal Transduction Smooth muscle U‐73122
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Beschreibung
Zusammenfassung:	In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U‐73122 can potently inhibit Ca2+ release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the sarcoplasmic/endoplasmic reticulum calcium ATPase pump in smooth muscle and cast doubt on the reliability of U‐73122 as the main pharmacological tool to assess the role of the phosphotidyl inositol‐PLC pathway in cellular signalling. This article is a commentary on MacMillan and McCarron, pp. 1295–1301 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476‐5381.2010.00771.x
ISSN:	0007-1188 1476-5381 1476-5381
DOI:	10.1111/j.1476-5381.2010.00795.x