Room-Temperature Aromatization of Tetrahydro-β-carbolines by 2-Iodoxybenzoic Acid: Utility in a Total Synthesis of Eudistomin U

Room-Temperature Aromatization of Tetrahydro-β-carbolines by 2-Iodoxybenzoic Acid: Utility in a Total Synthesis of Eudistomin U

2-Iodoxybenzoic acid is a convenient reagent for the dehydrogenation of tetrahydro-β-carbolines to their aromatic forms under mild conditions. The utility of the method was demonstrated in a total synthesis of the marine indole alkaloid eudistomin U.

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Veröffentlicht in:Organic letters 2010-09, Vol.12 (18), p.4086-4089
Hauptverfasser: Panarese, Joseph D, Waters, Stephen P
Format: Artikel
Sprache:eng
Schlagworte:
Carbolines - chemical synthesis
Carbolines - chemistry
Iodobenzenes
Iodobenzoates - chemistry
Molecular Structure
Temperature
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Zusammenfassung:2-Iodoxybenzoic acid is a convenient reagent for the dehydrogenation of tetrahydro-β-carbolines to their aromatic forms under mild conditions. The utility of the method was demonstrated in a total synthesis of the marine indole alkaloid eudistomin U.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101688x