Antiproliferative Triterpenoid Saponins of Dodonaea viscosa from the Madagascar Dry Forest

Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-09, Vol.72 (9), p.1705-1707
Hauptverfasser:	Cao, Shugeng, Brodie, Peggy, Callmander, Martin, Randrianaivo, Richard, Razafitsalama, Jeremi, Rakotobe, Etienne, Rasamison, Vincent E, TenDyke, Karen, Shen, Yongchun, Suh, Edward M, Kingston, David G. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor Female General pharmacology Humans Madagascar Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Sapindaceae - chemistry Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC50 values of 0.79 and 0.70 μM, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np900293x