Jamming the ratchet of transcription

The exact mechanism by which cellular RNA polymerases translocate and maintain exceptionally high fidelity during transcription remains an important unresolved issue. Two recent structural studies of yeast RNA polymerase II in complex with its potent inhibitor, the fungal toxin α-amanitin, address t...

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Veröffentlicht in:	Nature structural & molecular biology 2008-08, Vol.15 (8), p.777-779
Hauptverfasser:	Svetlov, Vladimir, Nudler, Evgeny
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Amanitin - chemistry Biochemistry Biological Microscopy Biomedical and Life Sciences Cellular biology DNA - chemistry Fungal Proteins - chemistry Gene Deletion Genetic transcription Life Sciences Membrane Biology Models, Biological Models, Molecular Molecular biology news-and-views Nucleotides - chemistry Physiological aspects Protein Conformation Protein Structure Protein Structure, Secondary Protein Transport RNA polymerase RNA Polymerase II - metabolism RNA polymerases Structure Toxins Transcription, Genetic Yeast Yeasts
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Beschreibung
Zusammenfassung:	The exact mechanism by which cellular RNA polymerases translocate and maintain exceptionally high fidelity during transcription remains an important unresolved issue. Two recent structural studies of yeast RNA polymerase II in complex with its potent inhibitor, the fungal toxin α-amanitin, address this matter by describing crucial and surprising details about the dynamic organization of the enzyme catalytic center.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/nsmb0808-777