Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epithelia

Alveolar epithelial cells (AEC) maintain integrity of the blood-gas barrier with gasket-like intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We hypothesize that stretch rapidly reorganizes actin (

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Bibliographische Detailangaben
Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2010-08, Vol.299 (2), p.C345-C353
Hauptverfasser:	DiPaolo, Brian C, Lenormand, Guillaume, Fredberg, Jeffrey J, Margulies, Susan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Actins - physiology Airway Remodeling - physiology Animals Biomechanical Phenomena - physiology Cell adhesion & migration Cell Line, Tumor Cells Cells, Cultured Cytoskeleton Cytoskeleton - chemistry Cytoskeleton - physiology Humans Lung diseases Male Membranes Protein and Vesicle Trafficking, Cytoskeleton Proteins Pulmonary Alveoli - chemistry Pulmonary Alveoli - cytology Pulmonary Alveoli - physiology Pulmonary Stretch Receptors - chemistry Pulmonary Stretch Receptors - cytology Pulmonary Stretch Receptors - physiology Rats Rats, Sprague-Dawley Respiratory Mucosa - chemistry Respiratory Mucosa - cytology Respiratory Mucosa - physiology Rodents Surface Properties Time Factors
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Beschreibung
Zusammenfassung:	Alveolar epithelial cells (AEC) maintain integrity of the blood-gas barrier with gasket-like intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We hypothesize that stretch rapidly reorganizes actin (
ISSN:	0363-6143 1522-1563
DOI:	10.1152/ajpcell.00379.2009