A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese
Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk. We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese. A population-based study includ...
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| Veröffentlicht in: | Diabetes care 2010-09, Vol.33 (9), p.1925-1932 |
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| container_title | Diabetes care |
| container_volume | 33 |
| creator | LIANG SUN ZHIJIE YU HU, Frank B XU LIN XINGWANG YE SHURONG ZOU HUAIXING LI DANXIA YU HONGYU WU YAN CHEN DORE, Joel CLEMENT, Karine |
| description | Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk. We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese.
A population-based study including 559 overweight/obese (BMI >or=24.0 kg/m(2)) and 500 normal-weight (18.0 |
| doi_str_mv | 10.2337/dc10-0340 |
| format | Article |
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A population-based study including 559 overweight/obese (BMI >or=24.0 kg/m(2)) and 500 normal-weight (18.0 <or= BMI <24.0 kg/m(2)) subjects aged 35-54 years was conducted in Shanghai, China. Fasting plasma glucose, lipid profile, LBP, high-sensitivity C-reactive protein, interleukin-6, high-molecular-weight (HMW) adiponectin, leptin, hepatic enzymes, and body composition were measured. Metabolic syndrome was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans.
LBP levels were significantly higher in overweight/obese individuals than in normal-weight individuals (geometric mean 27.6 [95% CI 25.2-30.3] vs. 10.0 [9.1-11.1] microg/ml; P < 0.001). After multiple adjustments including BMI, the odds ratios were 3.54 (95% CI 2.05-6.09) and 5.53 (95% CI 2.64-11.59) for metabolic syndrome and type 2 diabetes, respectively, comparing the highest with the lowest LBP quartile. Further adjustments for inflammatory markers almost abolished the significant association of LBP with metabolic syndrome but not that with type 2 diabetes, and controlling for adipokines and hepatic enzymes did not substantially alter the results.
Elevated circulating LBP was associated with obesity, metabolic syndrome, and type 2 diabetes in apparently healthy Chinese. These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc10-0340</identifier><identifier>PMID: 20530747</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Acute-Phase Proteins ; Adiponectin - blood ; Adult ; Asians ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Carrier Proteins - blood ; Cholesterol ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endotoxemia - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Insulin resistance ; Interleukin-6 - blood ; Leptin - blood ; Male ; Medical research ; Medical sciences ; Medicine, Experimental ; Membrane Glycoproteins - blood ; Metabolic diseases ; Metabolic disorders ; Metabolic Syndrome - blood ; Middle Aged ; Miscellaneous ; Obesity ; Obesity - blood ; Original Research ; Public health. Hygiene ; Public health. Hygiene-occupational medicine</subject><ispartof>Diabetes care, 2010-09, Vol.33 (9), p.1925-1932</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 American Diabetes Association</rights><rights>Copyright American Diabetes Association Sep 2010</rights><rights>2010 by the American Diabetes Association. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-a1dc65e889bb000aa4abd83906170f408c73961d0d5a9efc74baf3e38e295f983</citedby><cites>FETCH-LOGICAL-c536t-a1dc65e889bb000aa4abd83906170f408c73961d0d5a9efc74baf3e38e295f983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23238333$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20530747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIANG SUN</creatorcontrib><creatorcontrib>ZHIJIE YU</creatorcontrib><creatorcontrib>HU, Frank B</creatorcontrib><creatorcontrib>XU LIN</creatorcontrib><creatorcontrib>XINGWANG YE</creatorcontrib><creatorcontrib>SHURONG ZOU</creatorcontrib><creatorcontrib>HUAIXING LI</creatorcontrib><creatorcontrib>DANXIA YU</creatorcontrib><creatorcontrib>HONGYU WU</creatorcontrib><creatorcontrib>YAN CHEN</creatorcontrib><creatorcontrib>DORE, Joel</creatorcontrib><creatorcontrib>CLEMENT, Karine</creatorcontrib><title>A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk. We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese.
A population-based study including 559 overweight/obese (BMI >or=24.0 kg/m(2)) and 500 normal-weight (18.0 <or= BMI <24.0 kg/m(2)) subjects aged 35-54 years was conducted in Shanghai, China. Fasting plasma glucose, lipid profile, LBP, high-sensitivity C-reactive protein, interleukin-6, high-molecular-weight (HMW) adiponectin, leptin, hepatic enzymes, and body composition were measured. Metabolic syndrome was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans.
LBP levels were significantly higher in overweight/obese individuals than in normal-weight individuals (geometric mean 27.6 [95% CI 25.2-30.3] vs. 10.0 [9.1-11.1] microg/ml; P < 0.001). After multiple adjustments including BMI, the odds ratios were 3.54 (95% CI 2.05-6.09) and 5.53 (95% CI 2.64-11.59) for metabolic syndrome and type 2 diabetes, respectively, comparing the highest with the lowest LBP quartile. Further adjustments for inflammatory markers almost abolished the significant association of LBP with metabolic syndrome but not that with type 2 diabetes, and controlling for adipokines and hepatic enzymes did not substantially alter the results.
Elevated circulating LBP was associated with obesity, metabolic syndrome, and type 2 diabetes in apparently healthy Chinese. These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results.</description><subject>Acute-Phase Proteins</subject><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Asians</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Carrier Proteins - blood</subject><subject>Cholesterol</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endotoxemia - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Interleukin-6 - blood</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine, Experimental</subject><subject>Membrane Glycoproteins - blood</subject><subject>Metabolic diseases</subject><subject>Metabolic disorders</subject><subject>Metabolic Syndrome - blood</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Original Research</subject><subject>Public health. Hygiene</subject><subject>Public health. 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We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese.
A population-based study including 559 overweight/obese (BMI >or=24.0 kg/m(2)) and 500 normal-weight (18.0 <or= BMI <24.0 kg/m(2)) subjects aged 35-54 years was conducted in Shanghai, China. Fasting plasma glucose, lipid profile, LBP, high-sensitivity C-reactive protein, interleukin-6, high-molecular-weight (HMW) adiponectin, leptin, hepatic enzymes, and body composition were measured. Metabolic syndrome was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans.
LBP levels were significantly higher in overweight/obese individuals than in normal-weight individuals (geometric mean 27.6 [95% CI 25.2-30.3] vs. 10.0 [9.1-11.1] microg/ml; P < 0.001). After multiple adjustments including BMI, the odds ratios were 3.54 (95% CI 2.05-6.09) and 5.53 (95% CI 2.64-11.59) for metabolic syndrome and type 2 diabetes, respectively, comparing the highest with the lowest LBP quartile. Further adjustments for inflammatory markers almost abolished the significant association of LBP with metabolic syndrome but not that with type 2 diabetes, and controlling for adipokines and hepatic enzymes did not substantially alter the results.
Elevated circulating LBP was associated with obesity, metabolic syndrome, and type 2 diabetes in apparently healthy Chinese. These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>20530747</pmid><doi>10.2337/dc10-0340</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2010-09, Vol.33 (9), p.1925-1932 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute-Phase Proteins Adiponectin - blood Adult Asians Biological and medical sciences C-Reactive Protein - metabolism Cardiovascular disease Carrier Proteins - blood Cholesterol Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endotoxemia - blood Enzyme-Linked Immunosorbent Assay Female Humans Insulin resistance Interleukin-6 - blood Leptin - blood Male Medical research Medical sciences Medicine, Experimental Membrane Glycoproteins - blood Metabolic diseases Metabolic disorders Metabolic Syndrome - blood Middle Aged Miscellaneous Obesity Obesity - blood Original Research Public health. Hygiene Public health. Hygiene-occupational medicine |
| title | A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese |
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