Design and Investigation of a Series of Rhodamine-Based Fluorescent Probes for Optical Measurements of pH

Design and Investigation of a Series of Rhodamine-Based Fluorescent Probes for Optical Measurements of pH

A series of structurally similar fluorescent probes (1−4), synthesized from rhodamine B, were designed to optically measure pH. Each probe had a unique “off−on” response as the solution went from basic to acidic. Probes 1−3 exhibited a spirocyclic quenching of the pyronin B fluorophore, whereas prob...

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Veröffentlicht in:Organic letters 2010-07, Vol.12 (14), p.3219-3221
Hauptverfasser: Best, Quinn A, Xu, Ruisong, McCarroll, Matthew E, Wang, Lichang, Dyer, Daniel J
Format: Artikel
Sprache:eng
Schlagworte:
Drug Design
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Hydrogen-Ion Concentration
Optical Phenomena
Rhodamines - chemistry
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Zusammenfassung:A series of structurally similar fluorescent probes (1−4), synthesized from rhodamine B, were designed to optically measure pH. Each probe had a unique “off−on” response as the solution went from basic to acidic. Probes 1−3 exhibited a spirocyclic quenching of the pyronin B fluorophore, whereas probe 4 was quenched by PET from the amine moiety.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1011967