Short-term Hypoxia Increases Tyrosine Hydroxylase Immunoreactivity in Rat Carotid Body

Short-term Hypoxia Increases Tyrosine Hydroxylase Immunoreactivity in Rat Carotid Body

Neurochemical and morphological changes in the carotid body are induced by chronic hypoxia, leading to regulation of ventilation. In this study, we examined the time courses of changes in immunohistochemical intensity for tyrosine hydroxylase (TH) and cellular volume of glomus cells in rats exposed...

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Veröffentlicht in:The journal of histochemistry and cytochemistry 2010-09, Vol.58 (9), p.839-846
Hauptverfasser: Kato, Kouki, Yamaguchi-Yamada, Misuzu, Yamamoto, Yoshio
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carotid Body - enzymology
Fluorescent Antibody Technique
Hypoxia - enzymology
Immunoblotting
Male
Rats
Rats, Wistar
Time Factors
Tyrosine 3-Monooxygenase - metabolism
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Zusammenfassung:Neurochemical and morphological changes in the carotid body are induced by chronic hypoxia, leading to regulation of ventilation. In this study, we examined the time courses of changes in immunohistochemical intensity for tyrosine hydroxylase (TH) and cellular volume of glomus cells in rats exposed to hypoxia (10% O2) for up to 24 hr. Grayscale intensity for TH immunofluorescence was significantly increased in rats exposed to hypoxia for 12, 18, and 24 hr compared with control rats (p
ISSN:0022-1554
1551-5044
DOI:10.1369/jhc.2010.956250