Association between Common Variation in Genes Encoding Sweet Taste Signaling Components and Human Sucrose Perception
Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence var...
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Veröffentlicht in: | Chemical senses 2010-09, Vol.35 (7), p.579-592 |
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description | Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African–American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10−3 to 10−4), which encodes the taste-specific Gα protein subunit gustducin. Subsequent sequencing identified additional GNAT3 variations having significant association with sucrose AUC scores. Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception. |
doi_str_mv | 10.1093/chemse/bjq063 |
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Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African–American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10−3 to 10−4), which encodes the taste-specific Gα protein subunit gustducin. Subsequent sequencing identified additional GNAT3 variations having significant association with sucrose AUC scores. Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception.</description><identifier>ISSN: 0379-864X</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bjq063</identifier><identifier>PMID: 20660057</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>association ; Biological and medical sciences ; Cells, Cultured ; Computational Biology ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; genetic variations ; gustducin ; Humans ; Olfaction. Taste ; Perception ; Perception - physiology ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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For permissions, please e-mail: journals.permissions@oxfordjournals.org 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-35e618889c477d6f7617cbb1289f2351a146514023a6ad8947b00a4ac7c246673</citedby><cites>FETCH-LOGICAL-c552t-35e618889c477d6f7617cbb1289f2351a146514023a6ad8947b00a4ac7c246673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23154045$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20660057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fushan, Alexey A.</creatorcontrib><creatorcontrib>Simons, Christopher T.</creatorcontrib><creatorcontrib>Slack, Jay P.</creatorcontrib><creatorcontrib>Drayna, Dennis</creatorcontrib><title>Association between Common Variation in Genes Encoding Sweet Taste Signaling Components and Human Sucrose Perception</title><title>Chemical senses</title><addtitle>Chem Senses</addtitle><description>Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African–American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10−3 to 10−4), which encodes the taste-specific Gα protein subunit gustducin. Subsequent sequencing identified additional GNAT3 variations having significant association with sucrose AUC scores. Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception.</description><subject>association</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Computational Biology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>genetic variations</subject><subject>gustducin</subject><subject>Humans</subject><subject>Olfaction. Taste</subject><subject>Perception</subject><subject>Perception - physiology</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Signal Transduction - genetics</subject><subject>sucrose</subject><subject>Sucrose - pharmacology</subject><subject>Taste - genetics</subject><issn>0379-864X</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EokvhyBX5gnoK9beTC1K1Kl3USoC2oIqLNXGcrUvibO2Ej_8eR7ts4cTJsufnN_PmIfSSkjeUVPzU3ro-udP67p4o_ggtqFCi4FLyx2hBuK6KUombI_QspTtCqOCsfIqOGFGKEKkXaDxLabAeRj8EXLvxh3MBL4e-z9cvEPcFH_CFCy7h82CHxocNXmdwxNeQRofXfhOgm1_zx-0QXBgThtDg1dRDwOvJxiE5_NFF67az3nP0pIUuuRf78xh9fnd-vVwVVx8u3i_PrgorJRuzC6doWZaVFVo3qtWKalvXlJVVy7ikkL1KKgjjoKApK6FrQkCA1ZYJpTQ_Rm93utup7l1j82AROrONvof4ywzgzb-V4G_NZvhuWMWEYLPAyV4gDveTS6PpfbKu6yC4YUpGy7l_ScT_SVFWFcm2MlnsyHkrKbr2MA8lZo7U7CI1u0gz_-pvEwf6T4YZeL0HIFno2gjB-vTAcSoFEfKhsc-h_TzUIX4zeVdamtXNV_NJV8tLJi4N4b8B7Rq76w</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Fushan, Alexey A.</creator><creator>Simons, Christopher T.</creator><creator>Slack, Jay P.</creator><creator>Drayna, Dennis</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Association between Common Variation in Genes Encoding Sweet Taste Signaling Components and Human Sucrose Perception</title><author>Fushan, Alexey A. ; Simons, Christopher T. ; Slack, Jay P. ; Drayna, Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-35e618889c477d6f7617cbb1289f2351a146514023a6ad8947b00a4ac7c246673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>association</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Computational Biology</topic><topic>Fundamental and applied biological sciences. 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Psychophysiology</topic><topic>Signal Transduction - genetics</topic><topic>sucrose</topic><topic>Sucrose - pharmacology</topic><topic>Taste - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fushan, Alexey A.</creatorcontrib><creatorcontrib>Simons, Christopher T.</creatorcontrib><creatorcontrib>Slack, Jay P.</creatorcontrib><creatorcontrib>Drayna, Dennis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fushan, Alexey A.</au><au>Simons, Christopher T.</au><au>Slack, Jay P.</au><au>Drayna, Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Common Variation in Genes Encoding Sweet Taste Signaling Components and Human Sucrose Perception</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem Senses</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>35</volume><issue>7</issue><spage>579</spage><epage>592</epage><pages>579-592</pages><issn>0379-864X</issn><eissn>1464-3553</eissn><coden>CHSED8</coden><abstract>Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African–American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10−3 to 10−4), which encodes the taste-specific Gα protein subunit gustducin. Subsequent sequencing identified additional GNAT3 variations having significant association with sucrose AUC scores. Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>20660057</pmid><doi>10.1093/chemse/bjq063</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | association Biological and medical sciences Cells, Cultured Computational Biology Fundamental and applied biological sciences. Psychology Genetic Variation genetic variations gustducin Humans Olfaction. Taste Perception Perception - physiology Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Signal Transduction - genetics sucrose Sucrose - pharmacology Taste - genetics |
title | Association between Common Variation in Genes Encoding Sweet Taste Signaling Components and Human Sucrose Perception |
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