Particle/Fluid Interface Replication as a Means of Producing Topographically Patterned Polydimethylsiloxane Surfaces for Deposition of Lipid Bilayers

A simple method to produce topographically patterned substrates from polydimethylsiloxane (PDMS) is presented. Surfaces with positively or negatively curved features, a combination of positively and negatively curved features or geometrically complex biomimetic features are fabricated. High‐quality lipid bilayers that conform to the topography of the substrates can be prepared, a characteristic useful for biophysical studies.