Measures of site resourcing predict virologic suppression, immunologic response and HIV disease progression following highly active antiretroviral therapy (HAART) in the TREAT Asia HIV Observational Database (TAHOD)

Objectives Surrogate markers of HIV disease progression are HIV RNA in plasma viral load (VL) and CD4 cell count (immune function). Despite improved international access to antiretrovirals, surrogate marker diagnostics are not routinely available in resource‐limited settings. Therefore, the objectiv...

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Veröffentlicht in:HIV medicine 2010-09, Vol.11 (8), p.519-529
Hauptverfasser: Oyomopito, R, Lee, MP, Phanuphak, P, Lim, PL, Ditangco, R, Zhou, J, Sirisanthana, T, Chen, YMA, Pujari, S, Kumarasamy, N, Sungkanuparph, S, Lee, CKC, Kamarulzaman, A, Oka, S, Zhang, FJ, Mean, CV, Merati, T, Tau, G, Smith, J, Li, PCK
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Sprache:eng
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Zusammenfassung:Objectives Surrogate markers of HIV disease progression are HIV RNA in plasma viral load (VL) and CD4 cell count (immune function). Despite improved international access to antiretrovirals, surrogate marker diagnostics are not routinely available in resource‐limited settings. Therefore, the objective was to assess effects of economic and diagnostic resourcing on patient treatment outcomes. Methods Analyses were based on 2333 patients initiating highly active antiretroviral therapy (HAART) from 2000 onwards. Sites were categorized by World Bank country income criteria (high/low) and annual frequency of VL (≥3, 1–2 or
ISSN:1464-2662
1468-1293
DOI:10.1111/j.1468-1293.2010.00822.x