Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model

Exogenous osteoprotegerin (OPG) gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine model of knee prosthesis failure. A titanium pin was implanted into mouse proxim...

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Veröffentlicht in:	Gene therapy 2010-10, Vol.17 (10), p.1262-1269
Hauptverfasser:	Zhang, L, Jia, T-H, Chong, A C M, Bai, L, Yu, H, Gong, W, Wooley, P H, Yang, S-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/61/51/201 631/61/54/993 692/698/690/797 Acid phosphatase (tartrate-resistant) Acid Phosphatase - genetics Acid Phosphatase - metabolism Analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Applied cell therapy and gene therapy Arthroplasty (knee) Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Bone implants Bones Care and treatment Cell Biology Cellular biology Complications and side effects Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Therapy - methods Genetic Vectors - genetics Health aspects Health. Pharmaceutical industry Human Genetics IL-1β Implants, Artificial Industrial applications and implications. Economical aspects Inflammation Isoenzymes - genetics Isoenzymes - metabolism Knee Prosthesis Medical sciences Methods Mice Mice, Inbred BALB C Nanotechnology original-article Osteoclasts Osteolysis Osteolysis - pathology Osteolysis - therapy Osteoprotegerin Osteoprotegerin - genetics Prostheses Prosthesis Prosthesis Failure Risk factors Rodents Synoviocytes Tartrate-Resistant Acid Phosphatase Tibia Titanium Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplants & implants Tumor necrosis factor-α Tumorigenesis Weight-Bearing
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