impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus

impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus

A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maxi...

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Veröffentlicht in:Medicinal chemistry research 2010-09, Vol.19 (7), p.690-697
Hauptverfasser: Ilić, Slavica B, Konstantinović, Sandra S, Savić, Dragiša S, Veljković, Vlada B, Gojgić-Cvijović, G
Format: Artikel
Sprache:eng
Schlagworte:
anatomy and morphology
Antibiotic production
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Schiff base
Streptomyces hygroscopicus
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Zusammenfassung:A media consisting of isatin-Schiff bases (isatin-3-thiosemicarbazone, isatin-3-semicarbazone, and isatin-3-phenylhydrazone) was developed to maximize the production of antibiotics Hexaene H-85 and Azalomycine B by Streptomyces hygroscopicus. The media isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 372 μg cm⁻³ for Hexaene H-85 and 118 μg cm⁻³ for Azalomycine B. The impact of modified media on soil morphology also was investigated.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-009-9223-7