Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents

OBJECTIVE: We evaluated the role of fatty liver in the alteration of insulin sensitivity and β-cell function in two groups of obese adolescents, differing in hepatic fat content (hepatic fat fraction [HFF]) but with similar intrabdominal intramyocellular lipid content (IMCL) and overall degree of ob...

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Veröffentlicht in:	Diabetes care 2010-08, Vol.33 (8), p.1817-1822
Hauptverfasser:	D'Adamo, Ebe, Cali, Anna M.G, Weiss, Ram, Santoro, Nicola, Pierpont, Bridget, Northrup, Veronika, Caprio, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Blood Glucose Body Composition Diabetes Fatty liver Fatty Liver - blood Fatty Liver - physiopathology Female Glucose Clamp Technique Glucose Tolerance Test Humans Insulin Insulin resistance Insulin Resistance - physiology Liver Magnetic Resonance Imaging Male Obesity Obesity - blood Obesity - physiopathology Obesity in adolescence Original Research Teenagers Youth
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Zusammenfassung:	OBJECTIVE: We evaluated the role of fatty liver in the alteration of insulin sensitivity and β-cell function in two groups of obese adolescents, differing in hepatic fat content (hepatic fat fraction [HFF]) but with similar intrabdominal intramyocellular lipid content (IMCL) and overall degree of obesity. RESEARCH DESIGN AND METHODS: We studied 23 obese adolescents with high HFF (HFF >5.5%) and 20 obese adolescents with low HFF (HFF
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc10-0284