Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals throu...

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Veröffentlicht in:Annual review of pharmacology and toxicology 2010-01, Vol.50 (1), p.295-322
Hauptverfasser: NISWENDER, Colleen M, CONN, P. Jeffrey
Format: Artikel
Sprache:eng
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Zusammenfassung:The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners. A great deal of progress has been made in determining the mechanisms by which mGluRs are activated, proteins with which they interact, and orthosteric and allosteric ligands that can modulate receptor activity. The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of mGluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, anxiety, depression, and schizophrenia.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev.pharmtox.011008.145533