NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

Metallo-β-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 β-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2...

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Veröffentlicht in:ACS medicinal chemistry letters 2010-07, Vol.1 (4), p.150-154
Hauptverfasser: Weide, Timo, Saldanha, S. Adrian, Minond, Dmitriy, Spicer, Timothy P, Fotsing, Joseph R, Spaargaren, Michael, Frère, Jean-Marie, Bebrone, Carine, Sharpless, K. Barry, Hodder, Peter S, Fokin, Valery V
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Sprache:eng
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Zusammenfassung:Metallo-β-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 β-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the β-lactam, imipenem, in Escherichia coli.
ISSN:1948-5875
1948-5875
DOI:10.1021/ml900022q