Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes
AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity....
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2010-07, Vol.16 (26), p.3249-3257 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Song, Mi-Young Bae, Ui-Jin Lee, Bong-Hee Kwon, Kang-Beom Seo, Eun-A Park, Sung-Joo Kim, Min-Sun Song, Ho-Joon Kwon, Keun-Sang Park, Jin-Woo Ryu, Do-Gon Park, Byung-Hyun |
| description | AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c... |
| doi_str_mv | 10.3748/wjg.v16.i26.3249 |
| format | Article |
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METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c...</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v16.i26.3249</identifier><identifier>PMID: 20614480</identifier><language>eng</language><publisher>United States: Baishideng</publisher><subject>Animals ; Base Sequence ; Cell Death - drug effects ; Cell Line ; Cytokines - antagonists & inhibitors ; Cytokines - toxicity ; Diabetes Mellitus, Experimental - prevention & control ; DNA Primers - genetics ; Hypoglycemic Agents - pharmacology ; In Vitro Techniques ; Insulin - metabolism ; Insulin Secretion ; Insulin-Secreting Cells - drug effects ; Insulin-Secreting Cells - pathology ; Insulin-Secreting Cells - physiology ; Interferon-gamma - antagonists & inhibitors ; Interferon-gamma - toxicity ; Interleukin-1beta - antagonists & inhibitors ; Interleukin-1beta - toxicity ; Male ; Mice ; Mice, Inbred ICR ; Nardostachys ; NF-kappa B - metabolism ; Nitric Oxide Synthase Type II - genetics ; Original ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction - drug effects</subject><ispartof>World journal of gastroenterology : WJG, 2010-07, Vol.16 (26), p.3249-3257</ispartof><rights>2010 Baishideng. All rights reserved. 2010</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-24691cf360f0ceaecc10ae3c9c1b80a68b68a6d47e9892040e79729064d79db03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900716/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900716/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20614480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Mi-Young</creatorcontrib><creatorcontrib>Bae, Ui-Jin</creatorcontrib><creatorcontrib>Lee, Bong-Hee</creatorcontrib><creatorcontrib>Kwon, Kang-Beom</creatorcontrib><creatorcontrib>Seo, Eun-A</creatorcontrib><creatorcontrib>Park, Sung-Joo</creatorcontrib><creatorcontrib>Kim, Min-Sun</creatorcontrib><creatorcontrib>Song, Ho-Joon</creatorcontrib><creatorcontrib>Kwon, Keun-Sang</creatorcontrib><creatorcontrib>Park, Jin-Woo</creatorcontrib><creatorcontrib>Ryu, Do-Gon</creatorcontrib><creatorcontrib>Park, Byung-Hyun</creatorcontrib><title>Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c...</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Cell Death - drug effects</subject><subject>Cell Line</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Cytokines - toxicity</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>DNA Primers - genetics</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulin-Secreting Cells - drug effects</subject><subject>Insulin-Secreting Cells - pathology</subject><subject>Insulin-Secreting Cells - physiology</subject><subject>Interferon-gamma - antagonists & inhibitors</subject><subject>Interferon-gamma - toxicity</subject><subject>Interleukin-1beta - antagonists & inhibitors</subject><subject>Interleukin-1beta - toxicity</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Nardostachys</subject><subject>NF-kappa B - metabolism</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Original</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Signal Transduction - drug effects</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkb9uFDEQhy0EIkegp0IuaPcY_8FeN0goAoIUQQO15bVn93zZs4-1k3A8Fg_CM8VRwgmqKWZ-32jmI-Qlg7XQsn9zs53W10ytI1drwaV5RFacM9PxXsJjsmIAujOC6xPyrJQtABfiLX9KTjgoJmUPK1K-uCXkUp3fHArduup2LpVI8WddnK90v-SKvhbqJhdTqdQfar6MCbuYwpXHQP_87jzOMw0tOSF1KdBSF9zX_CvX7GM6ToboBqxYnpMno5sLvniop-T7xw_fzs67i6-fPp-9v-i8YLx2XCrD_CgUjODRofcMHApvPBt6cKofVO9UkBpNbzhIQG00N6Bk0CYMIE7Ju3vu_mrYYfCY2k2z3S9x55aDzS7a_zspbuyUr22DgGaqAeAe4JdcyoLjMcvA3gmwTYBtAmwTYO8EtMirf3ceA38_3gZePzA3OU0_Yprs4PzlGGdsVGBcaQ5M3AIh5pO2</recordid><startdate>20100714</startdate><enddate>20100714</enddate><creator>Song, Mi-Young</creator><creator>Bae, Ui-Jin</creator><creator>Lee, Bong-Hee</creator><creator>Kwon, Kang-Beom</creator><creator>Seo, Eun-A</creator><creator>Park, Sung-Joo</creator><creator>Kim, Min-Sun</creator><creator>Song, Ho-Joon</creator><creator>Kwon, Keun-Sang</creator><creator>Park, Jin-Woo</creator><creator>Ryu, Do-Gon</creator><creator>Park, Byung-Hyun</creator><general>Baishideng</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20100714</creationdate><title>Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes</title><author>Song, Mi-Young ; Bae, Ui-Jin ; Lee, Bong-Hee ; Kwon, Kang-Beom ; Seo, Eun-A ; Park, Sung-Joo ; Kim, Min-Sun ; Song, Ho-Joon ; Kwon, Keun-Sang ; Park, Jin-Woo ; Ryu, Do-Gon ; Park, Byung-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-24691cf360f0ceaecc10ae3c9c1b80a68b68a6d47e9892040e79729064d79db03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Cell Death - drug effects</topic><topic>Cell Line</topic><topic>Cytokines - antagonists & inhibitors</topic><topic>Cytokines - toxicity</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>DNA Primers - genetics</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulin-Secreting Cells - drug effects</topic><topic>Insulin-Secreting Cells - pathology</topic><topic>Insulin-Secreting Cells - physiology</topic><topic>Interferon-gamma - antagonists & inhibitors</topic><topic>Interferon-gamma - toxicity</topic><topic>Interleukin-1beta - antagonists & inhibitors</topic><topic>Interleukin-1beta - toxicity</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Nardostachys</topic><topic>NF-kappa B - metabolism</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Original</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Signal Transduction - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Song, Mi-Young</creatorcontrib><creatorcontrib>Bae, Ui-Jin</creatorcontrib><creatorcontrib>Lee, Bong-Hee</creatorcontrib><creatorcontrib>Kwon, Kang-Beom</creatorcontrib><creatorcontrib>Seo, Eun-A</creatorcontrib><creatorcontrib>Park, Sung-Joo</creatorcontrib><creatorcontrib>Kim, Min-Sun</creatorcontrib><creatorcontrib>Song, Ho-Joon</creatorcontrib><creatorcontrib>Kwon, Keun-Sang</creatorcontrib><creatorcontrib>Park, Jin-Woo</creatorcontrib><creatorcontrib>Ryu, Do-Gon</creatorcontrib><creatorcontrib>Park, Byung-Hyun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Mi-Young</au><au>Bae, Ui-Jin</au><au>Lee, Bong-Hee</au><au>Kwon, Kang-Beom</au><au>Seo, Eun-A</au><au>Park, Sung-Joo</au><au>Kim, Min-Sun</au><au>Song, Ho-Joon</au><au>Kwon, Keun-Sang</au><au>Park, Jin-Woo</au><au>Ryu, Do-Gon</au><au>Park, Byung-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2010-07-14</date><risdate>2010</risdate><volume>16</volume><issue>26</issue><spage>3249</spage><epage>3257</epage><pages>3249-3257</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c...</abstract><cop>United States</cop><pub>Baishideng</pub><pmid>20614480</pmid><doi>10.3748/wjg.v16.i26.3249</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2010-07, Vol.16 (26), p.3249-3257 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Base Sequence Cell Death - drug effects Cell Line Cytokines - antagonists & inhibitors Cytokines - toxicity Diabetes Mellitus, Experimental - prevention & control DNA Primers - genetics Hypoglycemic Agents - pharmacology In Vitro Techniques Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - pathology Insulin-Secreting Cells - physiology Interferon-gamma - antagonists & inhibitors Interferon-gamma - toxicity Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - toxicity Male Mice Mice, Inbred ICR Nardostachys NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Original Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Signal Transduction - drug effects |
| title | Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes |
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