Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity....

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Veröffentlicht in:	World journal of gastroenterology : WJG 2010-07, Vol.16 (26), p.3249-3257
Hauptverfasser:	Song, Mi-Young, Bae, Ui-Jin, Lee, Bong-Hee, Kwon, Kang-Beom, Seo, Eun-A, Park, Sung-Joo, Kim, Min-Sun, Song, Ho-Joon, Kwon, Keun-Sang, Park, Jin-Woo, Ryu, Do-Gon, Park, Byung-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Death - drug effects Cell Line Cytokines - antagonists & inhibitors Cytokines - toxicity Diabetes Mellitus, Experimental - prevention & control DNA Primers - genetics Hypoglycemic Agents - pharmacology In Vitro Techniques Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - pathology Insulin-Secreting Cells - physiology Interferon-gamma - antagonists & inhibitors Interferon-gamma - toxicity Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - toxicity Male Mice Mice, Inbred ICR Nardostachys NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Original Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Signal Transduction - drug effects
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Beschreibung
Zusammenfassung:	AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c...
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v16.i26.3249