A novel interaction between HER2/neu and cyclin E in breast cancer

HER2/neu (HER2) and cyclin E are important prognostic indicators in breast cancer. As both are involved in cell cycle regulation we analyzed whether there was a direct interaction between the two. HER2 and cyclin E expression levels were determined in 395 breast cancer patients. Patients with HER2-o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2010-07, Vol.29 (27), p.3896-3907
Hauptverfasser:	Mittendorf, E A, Liu, Y, Tucker, S L, McKenzie, T, Qiao, N, Akli, S, Biernacka, A, Meijer, L, Keyomarsi, K, Hunt, K K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/304 692/53/2422 692/699/67/1347 Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Care and treatment Cell Biology Cell cycle Cell cycle, cell proliferation Cell growth Cell Line, Tumor Cell physiology Cell proliferation Cell Proliferation - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell viability Cyclin E Cyclin E - chemistry Cyclin E - genetics Cyclin E - metabolism Cyclins Down-Regulation ErbB-2 protein Flow cytometry Fundamental and applied biological sciences. Psychology G1 phase G1 Phase - drug effects Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Isoforms Kinases Mammary gland diseases Medical prognosis Medical sciences Medicine Medicine & Public Health Mice Mice, Nude Molecular and cellular biology Molecular Weight Oncology original-article Patients Physiological aspects Prognosis Protein Binding Proteins Receptor, ErbB-2 - metabolism Risk factors Roscovitine Signal transduction Signal Transduction - drug effects siRNA Survival Rate Therapeutic targets Transcription, Genetic Transfection Trastuzumab Tumor cell lines Tumors Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	HER2/neu (HER2) and cyclin E are important prognostic indicators in breast cancer. As both are involved in cell cycle regulation we analyzed whether there was a direct interaction between the two. HER2 and cyclin E expression levels were determined in 395 breast cancer patients. Patients with HER2-overexpression and high levels of cyclin E had decreased 5-year disease-specific survival compared with low levels of cyclin E (14% versus 89%, P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2010.151