Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed t...

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Veröffentlicht in:	Nature genetics 2009-05, Vol.41 (5), p.524-526
Hauptverfasser:	Sawyers, Charles L, King, Jennifer C, Xu, Jin, Wongvipat, John, Hieronymus, Haley, Carver, Brett S, Leung, David H, Taylor, Barry S, Sander, Chris, Cardiff, Robert D, Couto, Suzana S, Gerald, William L
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Cancer Research Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Fusion Gene Function Genetic aspects Genetic engineering Genetics of eukaryotes. Biological and molecular evolution Health aspects Human Genetics Humans Kinases Male Mass spectrometry Medical research Mice Mice, Transgenic Molecular and cellular biology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Phosphatidylinositol 3-Kinases - metabolism Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Intraepithelial Neoplasia - metabolism Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - metabolism Protein kinases Proteins Risk factors Rodents Signal Transduction
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Zusammenfassung:	The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.371