Enzymatic Total Synthesis of Rabelomycin, an Angucycline Group Antibiotic

Enzymatic Total Synthesis of Rabelomycin, an Angucycline Group Antibiotic

A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vi...

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Veröffentlicht in:Organic letters 2010-06, Vol.12 (12), p.2814-2817
Hauptverfasser: Kharel, Madan Kumar, Pahari, Pallab, Lian, Hui, Rohr, Jürgen
Format: Artikel
Sprache:eng
Schlagworte:
Acetyl Coenzyme A - chemistry
Anthraquinones - chemical synthesis
Anthraquinones - chemistry
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Catalysis
Malonyl Coenzyme A - chemistry
Molecular Structure
Polyketide Synthases - metabolism
Streptomyces - chemistry
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Zusammenfassung:A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1009009