Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria

Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving...

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Veröffentlicht in:	Molecular interventions 2010-04, Vol.10 (2), p.98-111
Hauptverfasser:	Jones, Dean P, Lemasters, John J, Han, Derick, Boelsterli, Urs A, Kaplowitz, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical and Drug Induced Liver Injury Drug-Related Side Effects and Adverse Reactions Hepatocytes - drug effects Humans Liver - drug effects Metabolic Networks and Pathways - drug effects Mitochondria - drug effects Models, Biological Reviews
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Beschreibung
Zusammenfassung:	Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.
ISSN:	1534-0384 1543-2548
DOI:	10.1124/mi.10.2.7