Photothermal Effects of Supramolecularly Assembled Gold Nanoparticles for the Targeted Treatment of Cancer Cells

Laser‐triggered nanobomb: Size‐controlled gold supramolecular nanoparticles (Au‐SNPs) were synthesized from 2 nm gold colloids by a supramolecular self‐assembly approach. These Au‐SNPs exhibited significantly enhanced photothermal effects and could be used in conjunction with laser irradiation for t...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-05, Vol.49 (22), p.3777-3781
Hauptverfasser:	Wang, Shutao, Chen, Kuan-Ju, Wu, Ting-Hsiang, Wang, Hao, Lin, Wei-Yu, Ohashi, Minori, Chiou, Pei-Yu, Tseng, Hsian-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Fluorescent Dyes - chemistry gold Gold - chemistry Humans Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microscopy, Fluorescence nanoparticles Neoplasms - therapy Oligopeptides - chemistry Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology photothermal effects self-assembly tumor therapy
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Beschreibung
Zusammenfassung:	Laser‐triggered nanobomb: Size‐controlled gold supramolecular nanoparticles (Au‐SNPs) were synthesized from 2 nm gold colloids by a supramolecular self‐assembly approach. These Au‐SNPs exhibited significantly enhanced photothermal effects and could be used in conjunction with laser irradiation for the selective destruction of cancer cells (see picture) after the incorporation of a target‐specific ligand.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201000062