Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Three new sulfated sterol dimers, fibrosterol sulfates A−C (1−3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2009-08, Vol.74 (16), p.5902-5908
Hauptverfasser: Whitson, Emily L, Bugni, Tim S, Chockalingam, Priya S, Concepcion, Gisela P, Feng, Xidong, Jin, Guixian, Harper, Mary Kay, Mangalindan, Gina C, McDonald, Leonard A, Ireland, Chris M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Three new sulfated sterol dimers, fibrosterol sulfates A−C (1−3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhibited PKCζ with IC50 values of 16.4 and 5.6 μM, respectively.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo900844r