Parotid Gland Function After Radiotherapy: The Combined Michigan and Utrecht Experience

Purpose To analyze the combined and updated results from the University of Michigan and University Medical Center Utrecht on normal tissue complication probability (NTCP) of the parotid gland 1 year after radiotherapy (RT) for head-and-neck (HN) cancer. Patients and Methods A total of 222 prospectiv...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2010-10, Vol.78 (2), p.449-453
Hauptverfasser:	Dijkema, Tim, M.D, Raaijmakers, Cornelis P.J., Ph.D, Ten Haken, Randall K., Ph.D, Roesink, Judith M., M.D., Ph.D, Braam, Pètra M., M.D., Ph.D, Houweling, Anette C., M.Sc, Moerland, Marinus A., Ph.D, Eisbruch, Avraham, M.D, Terhaard, Chris H.J., M.D. Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences BODY Cancer DISEASES Dose-Response Relationship, Radiation DOSES Female FLOW RATE GLANDS HEAD Head and Neck Neoplasms - radiotherapy Head-and-neck cancer Hematology, Oncology and Palliative Medicine Humans Lethal Dose 50 Likelihood Functions Male Medical sciences MEDICINE Michigan Middle Aged Models, Biological NECK NEOPLASMS Netherlands NTCP NUCLEAR MEDICINE ORGANS Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Parotid Gland - physiopathology Parotid Gland - radiation effects Parotid gland function Prospective Studies RADIATION DOSES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Intensity-Modulated - adverse effects Radiotherapy, Intensity-Modulated - methods Salivation - physiology Salivation - radiation effects THERAPY Time Factors Tumors Xerostomia Xerostomia - etiology Young Adult
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Zusammenfassung:	Purpose To analyze the combined and updated results from the University of Michigan and University Medical Center Utrecht on normal tissue complication probability (NTCP) of the parotid gland 1 year after radiotherapy (RT) for head-and-neck (HN) cancer. Patients and Methods A total of 222 prospectively analyzed patients with various HN malignancies were treated with conventional and intensity-modulated RT. Stimulated individual parotid gland flow rates were measured before RT and 1 year after RT using Lashley cups at both centers. A flow ratio
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2009.07.1708