Pathology of EMT in Mouse Mammary Tumorigenesis

Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recent...

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Veröffentlicht in:	Journal of mammary gland biology and neoplasia 2010-06, Vol.15 (2), p.225-233
1. Verfasser:	Cardiff, Robert Darrell
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - pathology Cancer Research Cell Dedifferentiation Cell Transdifferentiation Disease Progression E-Cadherin Epithelial Cells - pathology Epithelial-mesenchymal-transition Female Genetically engineered mice Heterogeneity Humans Invasion Mammary Neoplasms, Experimental - pathology Medicine Medicine & Public Health Mesenchymal Stromal Cells - pathology metastasis Mice Mouse mammary tumors Oncology pathological processes and conditions snails Spindle cell phenotype
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Beschreibung
Zusammenfassung:	Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.
ISSN:	1083-3021 1573-7039
DOI:	10.1007/s10911-010-9184-y