A synthesis of the C1–C15 domain of the halichondrins
A concise route to the C1–C15 domain of the halichondrins is described. The key reaction is the conversion of a furfuryl alcohol to a pyranone. The stereocenter of this pyranone serves as the starting point for the other eight stereocenters.
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| Veröffentlicht in: | Tetrahedron letters 2008-04, Vol.49 (18), p.2939-2941 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A concise route to the C1–C15 domain of the halichondrins is described. The key reaction is the conversion of a furfuryl alcohol to a pyranone. The stereocenter of this pyranone serves as the starting point for the other eight stereocenters. |
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| ISSN: | 0040-4039 1873-3581 |
| DOI: | 10.1016/j.tetlet.2008.03.018 |