Attenuated and Lethal Variants of Pichindé Virus Induce Differential Patterns of NF-κB Activation Suggesting a Potential Target for Novel Therapeutics

Attenuated and Lethal Variants of Pichindé Virus Induce Differential Patterns of NF-κB Activation Suggesting a Potential Target for Novel Therapeutics

Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homod...

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Veröffentlicht in:Viral immunology 2009-12, Vol.22 (6), p.457-462
Hauptverfasser: Bowick, Gavin C., Fennewald, Susan M., Zhang, Lihong, Yang, Xianbin, Aronson, Judith F., Shope, Robert E., Luxon, Bruce A., Gorenstein, David G., Herzog, Norbert K.
Format: Artikel
Sprache:eng
Schlagworte:
Brief Reports
Cytokines
Health aspects
Physiological aspects
RNA viruses
Transcription factors
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Zusammenfassung:Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.
ISSN:0882-8245
1557-8976
DOI:10.1089/vim.2009.0034