Copper-Catalyzed Cyanation of Heterocycle Carbon−Hydrogen Bonds

Copper-Catalyzed Cyanation of Heterocycle Carbon−Hydrogen Bonds

A method for regioselective cyanation of heterocycles has been developed. A number of aromatic heterocycles as well as azulene can be cyanated in reasonable to good yields by using a copper cyanide catalyst and an iodine oxidant.

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Veröffentlicht in:Organic letters 2010-06, Vol.12 (11), p.2517-2519
Hauptverfasser: Do, Hien-Quang, Daugulis, Olafs
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Copper - chemistry
Iodine - chemistry
Molecular Structure
Nitriles - chemical synthesis
Nitriles - chemistry
Oxidation-Reduction
Stereoisomerism
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Beschreibung
Zusammenfassung:A method for regioselective cyanation of heterocycles has been developed. A number of aromatic heterocycles as well as azulene can be cyanated in reasonable to good yields by using a copper cyanide catalyst and an iodine oxidant.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100772u